Coming off their loss to the Seahawks and subsequent bye week, the Broncos returned home for an interconference duel against the Arizona Cardinals. The Cardinals grabbed the early lead, with a 33-yard field goal by placekicker Chandler Catanzaro. The Broncos then claimed the lead, with quarterback Peyton Manning throwing his 500th career touchdown pass &#8212; a 7-yarder to tight end Julius Thomas. Another field goal by Catanzaro &#8212; from 48 yards out, narrowed the Broncos' lead to 7-6. The Broncos expanded their lead midway through the second quarter, with Manning connecting on a 31-yard touchdown pass to wide receiver Demaryius Thomas. On the Broncos' next possession, Manning was intercepted by Cardinals' defensive end Calais Campbell deep in Broncos' territory. The Cardinals' offense capitalized on the next play, with a 5-yard touchdown run by running back Andre Ellington. After the two teams traded punts, Manning threw another touchdown pass to Demaryius Thomas &#8212; an 86-yarder just after the two-minute warning. The Broncos added to their lead in the third quarter, with a 44-yard field goal by placekicker Brandon McManus. Cardinals' quarterback Drew Stanton, playing in place of an injured Carson Palmer, was knocked out of the game with a concussion by Broncos' linebacker Von Miller. Later in the third quarter, third-string quarterback Logan Thomas threw an 81-yard touchdown pass to Ellington to narrow the Broncos' lead to 24-20. However, in the fourth quarter, the Broncos pulled away from the Cardinals and scored the final 17 points of the game, with a 41-yard field goal by McManus, a 12-yard touchdown pass from Manning to Julius Thomas and an 8-yard touchdown run by running back Juwan Thompson. The Broncos improved their all-time series record against the Cardinals to 8-1-1, and remained unbeaten in home games against the Cardinals (5-0).

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