Coming off their win over the Cowboys, the Eagles flew to New Meadowlands Stadium for an NFC East rivalry rematch against the New York Giants. In the first quarter the Eagles trailed early as Giants quarterback Eli Manning completed a 35-yard touchdown pass to wide receiver Mario Manningham. The Eagles responded in the second quarter with kicker David Akers getting a 34-yard field goal, but fell further behind after Manning found Manningham on a 33-yard touchdown pass, followed by kicker Lawrence Tynes nailing a 25-yard field goal, then with Manning getting an eight-yard touchdown pass to wide receiver Hakeem Nicks. The Eagles cut the lead with quarterback Michael Vick tossing an eight-yard touchdown pass to wide receiver Jeremy Maclin, but fell further behind with Manning finding tight end Kevin Boss on an eight-yard touchdown pass. However, the Eagles managed to break the lead and tie the game with Vick bombing a 65-yard TD pass to tight end Brent Celek, followed by his four-yard scramble for a touchdown and then his 13-yard touchdown pass to Maclin to tie the game at 31. After the game was tied the Eagles scored to take the lead with DeSean Jackson returning a punt 65 yards for a touchdown as time expired, becoming the first player in NFL history to do so. Fox commentator Joe Buck called the final play with: Eagles broadcasters Merrill Reese and Mike Quick called the play on WYSP-FM in Philadelphia this way:

How many yards was the longest touchdown run?
65