The Indianapolis Colts came into a crucial divisional matchup with the Jacksonville Jaguars, with added importance after the season opening loss to the Texans.  With the first possession of the ballgame, the Colts drove down the field with a mix of pass and run plays, scoring the opening touchdown of the game.  However, Jacksonville returned the favor by going 76&#160;yards to tie the game up, and by the end of the first quarter the game was tied at 7-7.  In the second quarter Maurice Jones-Drew scored on a touchdown run giving the Jaguars their first lead of the day, with the Colts eventually responded and tying the up 14-14 going into halftime.  With the beginning of the second half both teams failed to score on their next possessions, with the Colts punting to the Jaguars midway through the third quarter.  David Garrard threw his first touchdown pass of the day, giving the Jaguars a 21-14 lead towards the end of the third quarter.  With the Colts trailing midway through the fourth quarter, Peyton Manning drove the team down the field to score on a Joseph Addai run.  With the Jaguars responding and the Colts driving down the field to tie with 0:52 left, the game was a 28-28 with less than thirty seconds in the game.  Jacksonville was able to get two big plays on their last drive of the game setting up Josh Scobee for a 59-yard field goal, which was good.  The Indianapolis Colts started 0-2 in the AFC South for the first time following this loss, dropping out of first place and falling behind the Houston Texans.

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