The Panthers came into Week 5 again craving a win to get their season back on track. This time they were facing the former super bowl champions, the New Orleans Saints. The Saints were leading 10-0 with 3:04 left in the first quarter when Cam Newton threw a pass to wide receiver Steve Smith for a 54-yard touchdown after the touchdown Roman Harper was called for unnecessary roughness in the endzone. There would be a short fight after the play, and Olindo Mare would miss the extra point, it being blocked. With 4:01 left in the second quarter, the Panthers were trailing 17-6. Not when DeAngelo Williams took a left pitch from Cam Newton for a 69-yard score, Williams' first touchdown since 2009. Right before halftime, with 0:10 left, Sean Payton was trying to get the field goal unit out on the field for a John Kasay 46-yard field goal. Ron Rivera took a timeout because he thought he had too many men on the field, which would cost them a field goal which put the Saints up, 20-13. With 2:36 left in the third quarter, on a 2nd and 8, score 23-20 Saints, Drew Brees was intercepted by Sherrod Martin. Off of the interception, with 12:40 left in the game, on a 3rd and goal, Newton found Greg Olsen for a 5-yard touchdown to put the Panthers up 27-23. With 0:56 left in the game, Brees threw a short pass to Pierre Thomas for a six-yard score. Saints go up, 30-27. With 0:27 left, on a fourth-and-10, Cam Newton's pass is incomplete, intended for Greg Olsen, but there was a pass interference call on Roman Harper which set up a Panthers first down. Then, on a 3rd and 12 with 0:05 remaining, Cam Newton's pass, intended for Steve Smith is incomplete. With the close loss the Panthers fell to 1-4 on the season, though only being outscored 119-132 on the season.

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