The Giants' first loss of the year came in this much-anticipated "clash of unbeatens" against a 4-0 New Orleans team. Manning's first NFL game in his hometown of New Orleans was also Saints tight end Jeremy Shockey's first game against his former team. The Giants' defense, which entered the game as the best in the NFL, gave up 493 total yards and 7 touchdowns to seven different Saints, including Shockey. Scoring touchdowns for the Giants were: Bradshaw, on a 10-yard run in the second quarter; Manningham, who caught a 15-yard pass later in the quarter; and Nicks, whose 37-yard reception from Carr earned him his first career 100-yard receiving game. But the Giants were unable to overcome their highest-scoring opponent since 1999.

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