Coming off a 34-7 drubbing of the Arizona Cardinals, the Eagles (4-1) travelled to take on the Carolina Panthers (4-1). The Eagles drove into Panthers territory on their first possession of the game, but a Julius Peppers strip sack against Halapoulivaati Vaitai, who was filling in for a concussed Lane Johnson. The Panthers led 10-3, with their only TD coming from a 16-yard touchdown run from quarterback Cam Newton. Late in the second quarter, rookie cornerback Rasul Douglas intercepted Cam Newton deep in Panthers territory, leading to a Zach Ertz 1 yard touchdown reception. The Eagles opened up the second half with another Zach Ertz touchdown, a 17-yard strike from Carson Wentz. Leading 21-16 after three quarters, the Eagles opened up the fourth quarter with Carson Wentz hooking up with wide receiver Nelson Agholor for a 24-yard touchdown. Cam Newton led the Panthers on a long touchdown drive, trimming the score to 28-23. A late interception by cornerback Jalen Mills and a fourth down stop by the Eagles defense sealed the Eagles fifth victory of the season, and proved they were a legitimate contender in the NFC.

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