The Packers' home opener featured a rematch of the 2015 NFC Championship Game between the Packers and the Seattle Seahawks, who had won in their previous three meetings with the Packers, all of them in Seattle. The Packers got the early 13-3 lead, helped by James Jones' 3rd touchdown reception in only two games, but the Seahawks were able to rally back on two Russell Wilson touchdown passes, giving Seattle a 17-13 lead in the third quarter. The Packers then scored 14 unanswered points, aided by two Seahawks turnovers and shut down the Seahawks offense, holding their star running back, Marshawn Lynch, to only 42 yards rushing with a 2.7 yards per carry average. The Packers won 27-17, building up a 2-0 record and adding to a ten-game winning streak at Lambeau Field.

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