In the early 16th century, the present-day Myanmar  comprised several small kingdoms. The Ava Kingdom, the principal power in Upper Burma in the 14th and 15th centuries, had been fighting a long losing war against an alliance of its former vassal states: the Confederation of Shan States and Prome . Another former vassal state Toungoo , hemmed in by the Bago Yoma range in the west and the Shan Hills in the east, stayed out of the internecine warfare raging in Upper Burma. As the only peaceful state in Upper Burma, Toungoo had received a steady stream of refugees. Then, in 1527, the Confederation finally defeated Ava, and in 1532, its erstwhile ally Prome. Its paramount leader Sawlon I of Mohnyin had now reunited most of Upper Burma and cis-Salween Shan states for the first time since 1480. Toungoo, the only remaining holdout, was his "obvious next target." Fortunately for Toungoo, Sawlon I was assassinated in 1533 on his return trip from Prome, and his son and successor Thohanbwa, based out of Ava, was not accepted as the first among equals by other saophas  of the Confederation. Without a strong leader, the Confederation suddenly ceased to be a unified force capable of combined action.

What happened first, Sawlon I's assassination or the Confederation defeat of Ava?
A: Confederation finally defeated Ava

Despite three turnovers and a missed field goal in the first half, the Lions rebounded to dominate the Packers, earning their first win on Thanksgiving Day since 2003. After David Akers and Mason Crosby exchanged field goals, Green Bay took their first and only lead of the day in the second quarter when Nick Perry forced a Matthew Stafford fumble that Morgan Burnett returned for a 1-yard touchdown.  Detroit tied the score at 10 after Stafford found Jeremy Ross in the end zone with a 5-yard TD pass. A 1-yard Reggie Bush TD run gave the Lions a 17-10 halftime lead. The second half was all Lions. Calvin Johnson hauled in a 20-yard pass from Stafford for a 24-10 Lions lead.  Late in the third quarter, Ndamukong Suh sacked Matt Flynn in the end zone for a safety. After the ensuing free kick, Joique Bell finished off a 56-yard drive with a 1-yard TD run to put Detroit up 33-10. Kevin Ogletree completed the scoring by catching a 20-yard TD pass from Stafford to account for a 40-10 final score. Matthew Stafford was 22-of-35 passing, hitting nine different receivers for 330 yards and three touchdowns, while Reggie Bush had 182 yards from scrimmage (117 rushing, 65 receiving). With 101 yards receiving in the game, Calvin Johnson now has 4,944 receiving yards over the 2011 to 2013 seasons, surpassing Jerry Rice's previous NFL record for receiving yards over a three-season stretch (4,850 yards from 1993-95). The Lions offense outgained the Packers in the game 561 yards to 126 yards, while Detroit's defense sacked Matt Flynn seven times.

How many more yards did the Lions have over the Packers?
A: 435

John, the eldest son of King Manuel I to his second wife  Maria of Aragon, was born in Lisbon on 7 June 1502.  The event was marked by the presentation of Gil Vicente's Visitation Play or the Monologue of the Cowherd  in the queen's chamber. The young prince was sworn heir to the throne in 1503, the year his youngest sister, Isabella of Portugal, Empress Consort of the Holy Roman Empire between 1527 and 1538, was born. John was educated by notable scholars of the time, including the astrologer Tomás de Torres, Diogo de Ortiz, Bishop of Viseu, and Luís Teixeira Lobo, one of the first Portuguese Renaissance humanists, rector of the University of Siena  and Professor of Law at Ferrara . John's chronicler António de Castilho said that, "Dom João III faced problems easily, complementing his lack of culture with a practice formation that he always showed during his reign" . In 1514, he was given his own house, and a few years later began to help his father in administrative duties. At the age of sixteen, John was chosen to marry his first cousin, the 20-year-old Eleanor of Austria, eldest daughter of Philip the Handsome of Austria-Burgundy and Queen Joanna of Castile, but instead she married his widowed father Manuel. John took deep offence at this: his chroniclers say he became melancholic and was never quite the same. Some historians also claim this was one of the main reasons that John later became fervently religious, giving him name the Pious .

How many years old was John when his sister Isabella was born?
A:
1