The Colts headed to Gillette Stadium for a highly anticipated Sunday Night Football matchup with the New England Patriots in Week 9. In the first quarter, an interception in the end zone by Colts rookie FS Antoine Bethea set up the Colts' first scoring drive, a 68-yard march that ended with a 5-yard touchdown pass from QB Peyton Manning to WR Marvin Harrison for the only score of the quarter. Already banged up on defense, the Patriots lost SS Rodney Harrison to a shoulder injury in the first quarter, and he never returned to the game. The second quarter was a lot more eventful after two scores by Patriots RB Corey Dillon, a TD run by Colts rookie RB Joseph Addai, and a field goal by Colts kicker Adam Vinatieri. The Patriots played from behind for the rest of the game and could not catch up to the Colts. Patriots QB Tom Brady was intercepted four times in the defeat, and Colts LB Cato June intercepted two of those passes. Also of note, Colts WR Marvin Harrison had 8 catches in the game for 145 yards and two touchdowns. The victory marked the Colts' second straight versus the Patriots after having lost the previous six. With the win, the Colts became just the second team in NFL history to begin consecutive seasons 8-0 (the Green Bay Packers began three consecutive seasons 8-0 from 1929 to 1931). Also, with 326 yards passing QB Peyton Manning has thrown for over 300 yards in three consecutive games for the first time in his career.

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