Coming off their Week 2 road win over the Jaguars, the Cardinals went home for a Week 3 Sunday night interconference duel with the Indianapolis Colts.  Arizona took flight in the first quarter with kicker Neil Rackers' 38-yard field goal.  However, the Colts took a monster lead in the second quarter as quarterback Peyton Manning completed a 20-yard touchdown pass to wide receiver Reggie Wayne, a 10-yard touchdown pass to tight end Dallas Clark, and a 53-yard touchdown pass to wide receiver Pierre Gar&#231;on. The Cardinals tried to fight back in the third quarter as quarterback Kurt Warner hooked up with wide receiver Anquan Boldin on a 10-yard touchdown pass, but Indianapolis replied with Manning's 3-yard touchdown pass to running back Joseph Addai.  Afterwards, the Colts closed out the game in the fourth quarter with kicker Adam Vinatieri's 26-yard field goal.

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