As of the census of 2010, there were 520,116 people, 229,762 households, and 112,455 families residing in the city. The population density was 2,500.1 inhabitants per square mile (965.3/km²). There were 209,609 housing units at an average density of 1,076.7 per square mile (415.7/km²). The racial makeup of the city was 69.7% White (down from 94.8% in 1970), 5.0% Black or African-American, 2.7% Native American, 2.9% Asian, 0.2% Pacific Islander, 16.9% from other races, and 3.8% from two or more races. Hispanic or Latino of any race were 41.6% of the population. Non-Hispanic Whites were 47.2% of the population in 2010, down from 72.8% in 1970.

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