Coming off an impressive blowout of the Denver Broncos, the Texans packed up and traveled to Indianapolis to do battle with their division rival. Houston drew first blood with as QB Sage Rosenfels threw a 17-yard TD pass to Kevin Walter. The Colts responded to the TD with a 29-yard Vinatieri field goal. The Colts, who got off to a slow start in the 1st Quarter, scored three touchdowns in the 2nd quarter, a 2-yard TD run by Joseph Addai and two Peyton Manning TD passes to tight end Dallas Clark. In the 3rd quarter, the Colts continued to pull away from the struggling Texans. Clifton Dawson scored a 4-yard TD Run and Manning passed to Reggie Wayne for a 7-yard TD. In the 4th quarter, the Colts put in backups and QB Sage Rosenfels threw a 6-yard TD to Andre Johnson and Darius Walker rushed up the middle for the 2-Point Conversion. The Texans fell 38-15, ending their 2-game win streak and hopes for their first winning season.

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