After 5 straight victories, the 49ers dropped another home match following their bye. The Panthers' defense was too strong, limiting Colin Kaepernick to 91 yards, 0 touchdowns and 1 interception as the 49ers could only score 3 field goals. The mid-game loss of Tight End Vernon Davis and Safety Eric Reid to concussions did not aid the 49ers cause as they fell to 6-3. The 49ers would get their revenge in the Divisional Round of the Playoffs, winning 23-10 away to Carolina.

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