Hoping to snap a two-game losing streak, the Bills flew to The Meadowlands for a Week 15 AFC East rematch with the New York Jets.  With Trent Edwards still recovering from a groin injury, J.P. Losman was given the start. Early on in the first quarter, Buffalo trailed as Jets running back Thomas Jones got a 2-yard touchdown run.  The Bills responded with a 34-yard field goal from kicker Rian Lindell, but New York answered with quarterback Brett Favre completing an 11-yard touchdown pass to wide receiver Jerricho Cotchery.  In the second quarter, Buffalo took the lead as Losman got an 8-yard touchdown run and completed a 2-yard touchdown pass to rookie wide receiver Steve Johnson.  However, the Jets got the halftime lead with a 47-yard touchdown run from running back Leon Washington. In the third quarter, the Bills kept pace as Lindell made a 48-yard field goal. In the fourth quarter, New York responded with kicker Jay Feely's 31-yard field goal. Buffalo regained the lead as running back Fred Jackson powered his way for an 11-yard touchdown run.  However, the Jets prevailed as safety Abram Elam forced a fumble, allowing DE Shaun Ellis to return the ball 11 yards for a touchdown. With the loss, not only did the Bills fall to 6-8, but they were eliminated from the playoff race.

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