Coming off their win over the Raiders, the Broncos traveled to the Edward Jones Dome for an interconference match against the St. Louis Rams. The Rams grabbed the early lead on their first possession, with a 29-yard field goal by placekicker Greg Zuerlein. The Broncos were forced to punt on their first offensive possession. On the Broncos' next possession, tight end Julius Thomas suffered an ankle injury and did not return to the game. On the tenth play of the drive, the Broncos opted to go for a first-down on a 4th-and-5 from the Rams' 37-yard line rather than attempt a long field goal, however, a pass from quarterback Peyton Manning to wide receiver Emmanuel Sanders fell incomplete. On the very next play, the Rams extended to a 10-0 lead, with quarterback Shaun Hill connecting on a 63-yard touchdown pass to wide receiver Kenny Britt, with Britt evading a tackle by Broncos' cornerback Bradley Roby. The Rams' defense held the Broncos' offense in check on their next two possessions, and with four minutes remaining in the second quarter, Zuerlein added a 29-yard field goal to give the Rams a 13-0 lead. The Broncos subsequently got on the scoreboard on their next possession, with a 42-yard touchdown pass from Manning to Sanders just before the two-minute warning. On the fourth play of the Broncos' first possession of the second half, Sanders suffered a concussion after absorbing a helmet-to-helmet hit from Rams' safety Rodney McLeod, and did not return. However, after the 15-yard penalty, the Broncos could not advance the football from the Rams' 38-yard line, and were forced to punt. The Rams increased their lead to 16-7 later in their third quarter, with a 22-yard field goal by Zuerlein. On the Broncos' next possession, Manning was intercepted by Rams' linebacker Alec Ogletree, and seven plays later, a 55-yard field goal by Zuerlein increased the Rams' lead to 19-7 early in the fourth quarter. The Broncos advanced to as far as the Rams' 28-yard line on their next possession, and faced a 4th-and-4, however, Manning was sacked by Rams' defensive tackle Aaron Donald. The Broncos' defense subsequently forced a Rams' punt, however, Manning was intercepted by cornerback Trumaine Johnson on the Broncos' next possession. Four plays later, Zuerlein added a 53-yard field goal with 4:48 remaining in the game. With no timeouts remaining, the Broncos attempted a rally, but the Rams' defense stood their ground, and subsequently ran out most of the clock on offense. The Broncos accumulated only 28 rushing yards. The Rams' defense held the Broncos to 4-of-12 on third down and 0-of-3 on fourth down. This was the Broncos' lowest point total since Peyton Manning became the teams' starting quarterback in 2012. With his 389-yard performance, Manning now has at least one 300-yard passing game against every NFL team. However, his streak of 15 consecutive games with multiple touchdown passes came to an end.

How many yards was the longest touchdown play?
63-yard