Hoping to rebound from their road loss to the Giants, the Buccaneers went home for an NFC South rematch with the New Orleans Saints. In the first quarter, the Bucs trailed early as Saints QB Drew Brees completed a 15-yard TD pass to WR Marques Colston and a 52-yard TD pass to WR Devery Henderson. In the second quarter, kicker John Carney helped New Orleans improve its lead with a 46-yard field goal. Tampa Bay would valiantly fight back, as QB Bruce Gradkowski completed a 44-yard TD pass and a 17-yard TD pass to WR Joey Galloway, but that would be as close as they would get. In the third quarter, Saints pulled away with RB Deuce McAllister completing a 3-yard TD run and Bree completing a 45-yard TD pass to Henderson. With a scoreless second half, the Bucs would fall to 2-6.

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