Following their first road win of the season the previous week, the Texans traveled to Mexico City to face the Oakland Raiders in what would be a controversial game. Houston received the opening kickoff and Brock Osweiler found DeAndre Hopkins for a 60-yard touchdown pass and run, but Hopkins was ruled out of bounds after gaining 24 yards. The instant replayed showed that Hopkins stayed in bounds, but the play could not be challenged due to an NFL rule that says a play where a player is ruled out of bounds cannot be challenged. After the officiating error, the Texans' opening drive ended in a 32-yard field goal from Nick Novak. In the 4th quarter, with the game tied 20-20, the Texans made it to the Raiders' 16-yard line. On 3rd and 2, Lamar Miller ran the ball and appeared to have gained the 1st down, but was ruled just short. On 4th and inches, Houston decided to go for it and handed the ball off to Akeem Hunt. Hunt also appeared to have gained the 1st down, but was ruled short. The play was challenged, but the call was upheld. The spot of the ball on both plays was heavily criticized as both Miller and Hunt appeared to have gained enough yards for a 1st down. On the ensuing drive, Oakland would score the game-winning touchdown with a 35-yard pass from Derek Carr to Amari Cooper. Along the controversial officiating, a fan in the stands shined a laser pointer in the eyes of Osweiler and Miller throughout the game.

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