The Bills flew to Ford Field to take on the third of their four NFC North rivals, the Detroit Lions. From the start, the winless Lions were dominated the first quarter, as kicker Jason Hanson kicked a 43-yard FG, while Kevin Jones got a 7-yard run. In the second quarter, Buffalo got into the game, as J. P. Losman completed a 44-yard pass to Roscoe Parrish. However, Detroit responded, as Jon Kitna completed a 28-yard TD pass to Roy Williams. The Bills would get kicker Rian Lindell to get a 53-yard field goal to end the half. After a scoreless third quarter, Lions kicker Hanson got a 29-yard field goal, putting Detroit up 20-10. The Bills tried to catch-up, as Losman completed a 4-yard pass to Ryan Neufeld, but the deficit proved to be a little too much, as the Lions ended up getting their first win of the season at the Bills' expense, dropping the Bills to 2-4.

How many touchdowns did The Bills score in the first quarter?
1