Coming off their last-second home win over the Raiders, the Bills flew to the Edward Jones Dome for a Week 4 interconference duel with the winless St. Louis Rams.  In the first quarter, Buffalo drew first blood as kicker Rian Lindell got a 45-yard field goal.  The Rams responded with WR Donnie Avery getting a 37-yard TD run.  The Bills answered with Lindell's 35-yard field goal.  In the second quarter, St. Louis increased its lead with RB Steven Jackson getting a 29-yard TD run. In the third quarter, Buffalo began to rally as RB Fred Jackson got a 22-yard TD run.  In the fourth quarter, the Bills completed their comeback with CB Jabari Greer returning an interception 33 yards for a touchdown, QB Trent Edwards completing a 39-yard TD pass to WR Lee Evans, and Lindell nailing a 45-yard field goal. With the win, Buffalo got its first 4-0 start since 1992.

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