Hoping to rebound from their loss to the Chargers the Cardinals played on home ground for an NFC duel with the Saints. In the first quarter the Cardinals trailed early as kicker John Carney nailed a 31-yard field goal, followed by QB Drew Brees completing a 1-yard TD pass to TE Jeremy Shockey. The Cardinals replied with kicker Jay Feely making a 37-yard field goal, followed by OT Levi Brown recovering a fumble and returning it 2 yards for a touchdown. In the third quarter the Cardinals replied and took the lead when Feely got a 44-yard field goal, followed the 4th quarter by Feely's 29-yard field goal. Then FS Kerry Rhodes recovered a fumble and ran 27 yards to the endzone for a touchdown. The lead was broken down with Brees making a 35-yard TD pass to WR Robert Meachem, but the Cardinals managed to pull away when Brees' pass was intercepted by CB Dominique Rodgers-Cromartie and returned 28 yards to the endzone for a touchdown. With the win, Arizona went into their bye week at 3-2.

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