The Panthers' thirteenth game was an NFC South rivalry match against the Falcons. The Panthers trailed early as QB Matt Ryan completed a 4-yard TD pass to TE Tony Gonzalez, followed by RB Michael Turner getting a 1-yard TD run, and then with kicker Matt Bryant nailing a 39-yard field goal. The Panthers scored in the third quarter with RB Mike Goodson getting a 13-yard TD run, but the Falcons replied as Turner got a 3-yard TD run. The Panthers cut the lead as kicker John Kasay made a 36-yard field goal, but fell further behind as Turner got a 4-yard TD run.

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